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Two new prenylated flavonoid glycosides ( 1-2 ), together with five known compounds ( 3-7 ) were isolated from the EtOAc-soluble extract of the stems of  Celastrus orbiculatus . The structures of new compounds were elucidated with spectroscopic and physico-chemical analyses. All isolates were evaluated for  in vitro  cytotoxic activities against HepG2, MCF-7, A549, and A2780 cancer cells. Among them, compound  1  showed potential antiproliferative activity on A2780 cells with IC 50  value of 10.76 μM. In addition, compound  2  exhibited selective cytotoxic activity on A2780 cells with IC 50  value of 26.30 μM.

New prenylated flavonoid glycosides from the stems of Celastrus orbiculatus with their anti-tumor activities