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Three new diterpenoids, demethylfruticuline B ( 1 ), 20-hydroxyfruticuline B ( 2 ), and 6-hydroxyisofruticuline A ( 3 ) were isolated from the leaves of  Salvia lachnostachys  Benth, together with five known compounds: fruticuline B ( 4 ), fruticuline A ( 5 ), demethylfruticuline A ( 6 ), heterobetulinic acid ( 7 ), and maslinic acid ( 8 ). The known compounds  7 – 8  are being reported for the first time in this species. Compounds  1  and  4 – 6  were tested for antioxidant activity using the ORAC-FL method, and the antioxidant capacity was measured as relative trolox equivalent. All compounds were active, with values of relative trolox equivalent varying between 1.20–2.42. The most active compound was demethylfruticuline B ( 1 ).

Three new diterpenoids from the leaves of Salvia lachnostachys