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Two new  nor -lignans siamensinols A-B ( 1 – 2 ) and seven known compounds agatharesinol ( 3 ), syringaresinol-glucoside ( 4 ), noreugenin ( 5 ), 8-methyleugenitol ( 6 ), melachromone ( 7 ), uncinoside A ( 8 ) and daucosterol ( 9 ) were isolated from  Selaginella siamensis  Hieron. The structures of the new compounds were elucidated on the basis of comprehensive spectroscopic methods, including 1 D, 2 D-NMR, HR-ESI-MS and CD spectrometry. Compounds  1–2  showed moderate inhibitory effect on MOLT-3 cells while 8-methyleugenitol ( 6 ) exhibited moderate inhibitory effect on three tumor cells (HepG2, A549 and HuCCA-1). Compounds  2–3  showed the potent cancer chemoprevention in DPPH, XXO, IXO and AIA assays.

Two new nor -lignans, siamensinols A and B, from Selaginella siamensis Hieron. and their biological activities