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A series of  N -heteroaryl substituted Gallamide derivatives  3a-3g  were synthesised and the obtained structures were further confirmed by different spectral studies. For  in-vitro  antibacterial activity, the synthesised compounds were evaluated against three UTI (Urinary Tract Infection) bacterial strains including  Staphylococcus aureus, Escherichia coli,  and  Streptococcus pyogenes . Furthermore, the designed compounds were docked with bacterial DNA gyrase and dihydropteroate synthase. All the compounds had shown good inhibition against  S. aureus  whereas compound  3e  has produced significant inhibition at 28 and 26 mm against  S.aureus  and  E.coli,  respectively. The MIC value of the conjugate  3e  and  3d  was 3.12 and 6.25 μg/mL against  S. aureus  and E.coli,  respectively. Compound 3,4,5-trihydroxy- N -(4-( N -(5-methyl isoxazol-3-yl) sulfamoyl) phenyl)benzamide  3d  had shown the highest binding energy against both the targets along with good antibacterial action.

Design, molecular docking study of synthesised N -heteroaryl substituted gallamide derivatives and their antibacterial assessment