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Two undescribed ( 1 – 2)  and five known cyclic diarylheptanoids ( 3 – 7 ) were isolated from the false heartwood of white birch ( Betula pubescens  Ehrh.). All structures were elucidated through extensive 1D and 2D NMR experiments and HR-ESI-MS data, along with comparison of their spectroscopic data with those reported in the literature. The two new cyclic diarylheptanoids are betuladiol ( 1 ) and betulondiol ( 2 ). Extracts from false heartwood were evaluated for their antimicrobial activity against  Klebsiella pneumoniae ,  Escherichia coli ,  Proteus mirabilis, Staphylococcus aureus  and  Cutibacterium acnes  together with their antifungal activity against  Candida albicans  and  Candida glabrata .

New cyclic diarylheptanoids from the false heartwood of Betula pubescens Ehrh