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The naturally occurring compound andrographolide  1  was used as a substrate for the synthesis of a novel terminal alkyne  3  which on copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction with azides  4a-l ,  7  and  9  furnished a series of regioselective andrographolide triazolyl conjugates  5a-l, 8  and  10 , respectively. A free glycoconjugate  6  was also prepared by selective deprotection of compound  5i  in good yield. All the compounds were characterized by absorbance, FT-IR, NMR, and HR-MS analyses. The triazolyl conjugate  8  was further investigated as a probe for selective detection of Fe 3+  ion in matrix. The mode of attachment of Fe 3+  ion to the compound  8  was established by absorbance, fluorescence, infrared (IR), and nuclear magnetic resonance (NMR) spectroscopy, and high resolution mass-spectrometry (HR-MS). The logic gate circuits were constructed for the probe  8  and ethylenediaminetetraacetic acid (EDTA). The environmental perspective of probe  8  was investigated in real water samples.

Click chemistry inspired synthesis of andrographolide triazolyl conjugates for effective fluorescent sensing of ferric ions