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Withania somnifera ,  Angelica sinensis, Glycyrrhiza glabra , and  Simmondsia chinensis  were acquired from the Egyptian market, profiled for their chemical constituents, screened for the  in-vitro  MAO-B inhibitory activity and evaluated for the total phenolic content. Thirty compounds were characterized in the selected herbs using HPLC-MS/MS.  In-vitro  MAO-B inhibitory activity and total phenolic content of the acquired herbs were compared with those of a prepared herbal formula consisting of a mixture of equal amounts of the four mentioned herbs. The most potent MAO-B inhibitory activity was exerted by the methanol extract of the prepared formula (IC 50  of 712.19 ± 13.90 ng/mL) compared to selegiline (IC 50  of 581.69 ± 11.35 ng/mL). The highest value of the total phenolic content was shown by  Angelica sinensis  methanolic extract (76.15 ± 0.1 mg/g) followed by  Glycyrrhiza glabra  methanolic extract (65.74 ± 0.1 mg/g), then the mixture’s methanolic extract of the four herbs (37.04 ± 0.1 mg/g).

natural product research

Dismantling Parkinson’s disease with herbs: MAO-B inhibitory activity and quantification of chemical constituents using HPLC-MS/MS of Egyptian local market plants