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Five new compounds including, a neolignan, eupomatenoid-19 ( 1 ) and four polyoxygenated  seco -cyclohexenes, artahongkongenes G-J ( 2–5 ), together with fifteen known compounds ( 6–20 ) were isolated from the stems and leaves of  Piper suipigua  Buch.-Ham. ex D. Don. Their structures were determined by spectroscopic evidence (IR, UV,  1 H NMR,  13 C NMR and 2 D NMR) as well as MS. The absolute configurations of polyoxygenated  seco -cyclohexenes  2 – 8  were identified by NOESY data and by comparison of their experimental and calculated ECD spectral data. Neolignans, eupomatenoid-19 ( 1 ) and eupomatenoid-7 ( 10 ), displayed cytotoxicity against several cancer cell lines. In addition, eupomatenoid-7 ( 10 ) showed antibacterial activity against  Bacillus cereus ,  Bacillus subtilis  and  Staphylococcus aureus.

Neolignans and polyoxygenated seco -cyclohexenes from the stems and leaves of Piper suipigua Buch.-Ham. ex D. Don