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Two new organic acids, identified as (7 E ,9 E ,12 E )-pentadecyl-7,9,12-trienoic acid, named Oleraceacid A ( 1 ), and 6,7-dihydroxy-4-(4-hydroxy-3,5-dimethoxyphenyl)-2-naphthoic acid, named Oleraceacid B ( 2 ), were isolated from  Portulaca oleracea  L.. The structures were verified by spectroscopic methods, including UHPLC-ESI-QTOF/MS, 1 D and 2 D NMR. Both Oleraceacid A ( 1 ) and Oleraceacid B ( 2 ) at 20 μM inhibited the inflammatory factor, IL-1 β  in the RAW 264.7 cells induced by LPS, moreover, Oleraceacid A ( 1 ) can inhibit cholinesterase activity.

Two new organic acids from Portulaca oleracea L. and their anti-inflammatory and anticholinesterase activities