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The methanol extract of  Doronicum pardalianches  L. was fractionated using  n -hexane, chloroform, and ethyl acetate to evaluate their cholinesterase (ChE) inhibitory activity  via  modified Ellman’s method. It was perceived that only the ethyl acetate fraction was active toward acetylcholinesterase (AChE) with IC 50  value of 172.21 µg/mL. Also, all fractions showed no butyrylcholinesterase (BChE) inhibitory activity. The ethyl acetate fraction was also investigated for its neuroprotectivity and metal chelating ability (Zn 2+ , Fe 2+ , and Cu 2+ ) which demonstrated desired activity. Phytochemical analysis of the ethyl acetate fraction led to isolation and identification of formononetin 7- O -β-D-glucopyranoside which has not been previously reported for this plant.

Phytochemical investigation and biological activity of Doronicum pardalianches L. roots against Alzheimer’s disease