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A new xanthone glycoside, 1,8-dihydroxyl-2,5-dimethoxy-xanthone-6-O- β -D-glucoside ( 1 ), along with two known xanthone glycosides and two flavonoid glycosides were isolated from the aerial parts of  Lomatogonium rotatum  (L.) Fries es Nym. The structure of  1  was elucidated by analysis of its spectroscopic data, including UV, IR, HR-ESI-MS and extensive 1 D and 2 D NMR techniques. In vitro test, compound  1  behaved similarity to swertianolin against α‑glucosidase and more potent inhibitory effects than the positive control, acarbose.

Structural elucidation and α‑glucosidase inhibitory activity of a new xanthone glycoside from Lomatogonium rotatum (L.) Fries es Nym