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A new acetophenone dimer, 5′-prenylacrovestone ( 1 ), together with nineteen known compounds ( 2 – 20 ), were isolated from the stem bark of  Acronychia pedunculata  (L.) Miq. Their structures were identified by thorough analysis of spectroscopic (IR, 1D and 2D NMR) and mass spectrometric data. The isolated compounds were tested against the bacterial pathogens MRSA,  B. cereus ,  S. aureus  and  E. coli . Compound  3  demonstrated exceptionally potent antibacterial activity against each of the four strains (MIC values of 1 µg/mL).

A new polyphenolic isoprenylated acetophenone dimer from the stem bark of Acronychia pedunculata (L.) Miq