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Two new octahydronaphthalene derivatives, trichodermic acid C ( 1 ) and trichodermic acid D ( 2 ), along with known analogs, trichodermic acid ( 3 ), trichodermic acid A ( 4 ) and trichodermic acid B ( 5 ), were isolated from an ethyl acetate extract of endophytic strain  Trichoderma  sp. HN-1.1. The structures of compounds  1  and  2  were elucidated using spectroscopic methods including UV, IR, HRESITOFMS, ECD, 1 D and 2 D NMR. The cytotoxic activity of the isolated compounds was evaluated on the rat hepatoma cell line H4IIE, using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2 H -tetrazolium bromide (MTT) assay. According to the results, only compound  3  showed a significant reduction of H4IIE cells from 75 to 21% ( p  &lt; 0.01) with an IC 50  value of 50% cell survival estimated as 143.1 µM, which indicated weak cytotoxic activity.

Two new octahydronaphthalene derivatives, trichodermic acids C and D produced by Trichoderma sp. HN-1.1