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Bioactivity-guided fraction of an extract of  Sophora flavescens  to identify antibacterial compounds against  Acinetobacter baumannii , led to the isolation of two new compounds, (2″ R )-5-methoxy-7-hydroxy-8-lavandulylchromone (13) and (2 S , βS )-(-)-sophobiflavonoid CE (19), and 18 known flavonoids, (6a R ,11a R )-(-)-maackiain (1), (2 S )-(-)-8-prenylnaringenin (2), (2 S )-(-)-exiguaflavanone K (3), (2 S )-(-)-sophoraflavanone G (4), (2 S )-(-)-leachianone A (5), (2 S )-(-)-kushenol E (6), (2 S )-(-)-leachianone G (7), (±)-kushenol F (8), (2 S )-(-)-kurarinone (9), (2 S )-(-)-kurarinol (10), (2  R ,3 R )- (+)-3,7,4'-trihydroxy-5-methoxy-8-prenylflavanone (11), (2 S )-(-)-isoxanthohumol (12), (2 S )-(-)-2'-methoxykurarinone (14), (2  R ,3 R )-(+)-kushenol I (15), calycosin (16), kuraridin (17), (2 S )-(-)-kushenol A (18), and trifolirhizin (20). Their structures were elucidated based on NMR, MS, and CD spectroscopic analysis. Among them,  1 ,  2 ,  5 , and  15  exerted modest antibacterial activity against  A. baumannii , with MIC 95  of 128-256 μg/mL for  2  and 256-512 μg/mL for  1 ,  5  and  15 .

Bioactivity-guided isolation of compounds from Sophora flavescens with antibacterial activity against Acinetobacter baumannii