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Pseudorabies (PR) is an acute infectious disease caused by pseudorabies virus (PRV). There are no available drugs due to the emergence of variant of PRV. Dihydromyricetin (DMY) is a flavonoid extracted from  Ampelopsis grossedentata  ( A. grossedentata ), which has a variety of pharmacological activities. In this study, we aim to investigate the  in vitro  anti-PRV activity of DMY extracted from  A. grossedentata . MTT assay was used to detect the cytotoxicity and antiviral activity of DMY. The results detected by flow cytometry and qRT-PCR showed that DMY played anti-PRV role mainly by interfering with the process of virus invasion into host cell and inhibiting the occurrence of pyroptosis  in vitro.  This suggested that anti-pyroptosis may be an important antiviral mechanism for DMY which is expected to be a potential anti-PRV drug.

In vitro anti-PRV activity of dihydromyricetin from Ampelopsis grossedentata