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Chemical investigation of the whole plant of  Sauropus hirsutus  Beille led to the isolation of eight quinolines and two known flavonoids. Furthermore, five quinolines were new, two were reported in plant for the first time and one was known. Cytotoxicity evaluation against cholangiocarcinoma, KKU-M156, showed that the most active compound was 4-hydroxy-6-methoxy-7,8-methylenedioxyquinaldine (IC 50  20.54 ± 6.82 µM) which was a little more active than the cisplatin standard (IC 50  24.39 ± 1.14 µM).

Five new quinoline alkaloids from Sauropus hirsutus Beille and their cytotoxicity