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Two bioactive compounds caffeic and sinapic acid were isolated from the fruit of the  Piper mullesua  Buch–Ham ex D Don using bioassay guided approach. These compounds were isolated from water fraction using column chromatography followed by semi preparative HPLC. These compounds showed very potent anti-diabetic and antioxidant activities. The molecular docking was carried out to predict the mode of interaction of the isolated compounds with α-glucosidase. The  in vitro  α-glucosidase inhibitory activity of caffeic and sinapic acid was determined, and their IC 50  values were found 0.67 and 0.82 µg/ml, respectively. A QSAR equation was generated with an  R2  value of 84.81%, which is suitable enough for predicting the IC 50  values of test molecules. The aforementioned finding confirms the isolated compounds show very significant anti-diabetic potential which is supported by the molecular docking and QSAR study. So, it has ample scope for drug development with further  in vivo  and clinical study.

natural product research

Bioassay-guided isolation of potent α-glucosidase inhibitory compounds from the fruit of  Piper mullesua  Buch–Ham ex D Don. and their  in silico  screening