English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

A new indole diketopiperazine alkaloid, named penilline D ( 1 ), together with five known indole alkaloid analogues ( 2 – 5 ,  11 ), two meroterpenoids ( 6  and  12 ), and four butenolide derivatives ( 7 – 10 ), were isolated from the Antarctic fungus  Penicillium  sp. SCSIO 05705. Extensive spectroscopic analysis and electronic circular dichroism (ECD) calculation were used to elucidate the structure of penilline D ( 1 ), including its absolute configuration. All isolated compounds ( 1 – 12 ) were evaluated for their cytotoxic, antibacterial and enzyme inhibitory activities against acetylcholinesterase (AChE) and pancreatic lipase (PL). Among them, compound  5  exhibited moderate in vitro cytotoxic activity against the 143B cell line with IC 50  value of 12.64 ± 0.78 μM. Compound  6  showed strong inhibitory activity against AChE with IC 50  value of 0.36 nM (IC 50  18.7 nM for Tacrine), while compounds  6  and  11  showed weak PL enzyme inhibitory activity. Furthermore, an in silico molecular docking study was also performed between  6  and AChE.

Indole diketopiperazine alkaloids and aromatic polyketides from the Antarctic fungus Penicillium sp. SCSIO 05705