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2 β ,3 α ,19-Triacetoxy-17-hydroxyspongia-13(16),14-diene ( 1 ), a novel acetoxy diterpenoid, and 18-nor-2,17-hydroxyspongia-1,4,13(16),14-quaien-3-one ( 2 ), belonging to the rare 18-nor-spongian carbon skeleton, together with six related known metabolites ( 3 ‒ 8 ), were isolated from the aquaculture  Spongia officinalis  Linnaeus, 1759. Their structures were elucidated by comprehensive spectroscopic analysis, quantum chemical calculation of NMR parameters, and electronic circular dichroism (ECD). Compounds  3 ,  4 , and  5  exhibited moderate inhibition against STAT3/NF- κ B, HIF-1, Wnt signalling pathways. Compounds  1 ,  3 , and  5  showed cytotoxicity activities against K562 cell line with IC 50  values of 7.3, 3.5, and 6.4  μ M, respectively.

Two new spongian diterpene derivatives from the aquaculture sponge Spongia officinalis Linnaeus, 1759