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A new muurolane-type sesquiterpene, a new flavone arabinofuranoside derivative, and other five known flavone arabinofuranoside derivatives were isolated from the leaves of  Fissistigma bicolor  (Annonaceae family). Their chemical structures were determined to be (1 S ,6 R ,7 S )-muurola-4,10(14)-diene-15-ol ( 1 ), quercetin 3- O - β -D-apiofuranosyl-(1→2)- α -L-arabinofuranoside ( 2 ), quercetin 3- O - α -L-rhamnopyranosyl-(1→2)- α -L-arabinofuranoside ( 3 ), quercetin 3- O - α -L-arabinofuranoside ( 4 ), kaempferol 3- O - β -D-apiofuranosyl-(1→2)- α -L-arabinofuranoside ( 5 ), kaempferol 3- O - α -L-rhamnopyranosyl-(1→2)- α -L-arabinofuranoside ( 6 ), and kaempferol 3- O - α -L-arabinofuranoside ( 7 ) by analyses of HR-ESI-MS and NMR spectral data. Compounds  4  and  7  containing monosaccharide, arabinofuranoside, potentially inhibited NO productions in LPS activated RAW264.7 cells (IC 50  13.4 ± 0.5 and 12.6 ± 0.4 µM) in compared to disaccharide derivatives (IC 50  ranging from 58.9 ± 3.3 to 65.6 ± 3.8 µM).

New sesquiterpene and flavone arabinofuranoside derivative from the leaves of Fissistigma bicolor