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A new monoterpenoid glycoside (1  R , 2  R , 4 S )-1,8-epoxy- p -menthan-2- O - β -D-glucopyranosyl-(1→4)- β -D-glucopyranoside ( 1 ) and a new phenolic glycoside,  cis -1-(3-hydroxy-4-methoxyphenyl)-2-butene-4- O - α -L-rhamnopyranosyl-(1→3)- O - β -D-glucopyranoside ( 2 ) were isolated from the dried aerial parts of  Dracocephalum moldavica , together with 12 known compounds. Compound  5  was isolated from the Lamiaceae family for the first time, compounds  3 ,  4 ,  6  and  8 – 12  were identified from the genus  Dracocephalum  for the first time and compounds  7  and  13 – 14  were reported from the  D. moldavica  for the first time. All the compounds were evaluated for anti-complementary activity against the classical and alternative pathways. Compounds  2 – 4 ,  8  and  11  showed anti-complementary activity to different extents, with CH 50  and AP 50  values ranging from 0.78–1.24 and 1.52–1.84 mM, respectively. The targets of compounds  2 – 4 ,  8  and  11  in complement activation cascade were identified as well.

A new monoterpenoid glycoside and a new phenolic glycoside isolated from Dracocephalum moldavica and their anti-complementary activity