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Eight cadinane-type sesquiterpenes, including a new cadinane-type sesquiterpene, named as mappianiodene ( 1 ), and seven known analogues ( 2 – 8 ), were isolated and identified from the stems and leaves of  Mappianthus iodoides . The chemical structure and absolute configurations of  1  was elucidated by extensive spectral methods and the known compounds were identified by comparing their experimental spectral data with the reported spectral data in the literature. The anti-inflammatory and anti-HIV activities of those isolated cadinane-type sesquiterpenes were tested. As a result, cadinane-type sesquiterpenes  1 – 8  displayed notable inhibitory effects on NO (nitric oxide) production with IC 50  values equivalent to that of the hydrocortisone. Moreover, compounds  1 – 8  exhibited pronounced anti-HIV-1 reverse transcriptase (RT) activities with the EC 50  values in range of 0.17 to 9.28 µM.

Cadinane-type sesquiterpenes with potential anti-inflammatory and anti-HIV activities from the stems and leaves of Mappianthus iodoides