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We aimed to evaluate the chemical, antioxidant, cytotoxic, and antifungal activities of hydroalcoholic extracts of native plants from Southern Brazil:  Schinus terebinthifolia  (SCH) , Persicaria hydropiperoides  (PER) , Eugenia uniflora  (EUG) and  Equisetum hyemale  (EQU). Ethyl gallate, quercetin, and quinic acid were prevalent compounds identified by LC-MS. For total phenolic/flavonoid contents and the antioxidant potential against ABTS/DPPH radicals, the ascending order was EQU &lt; PER &lt; EUG &lt; SCH. All extracts were low cytotoxic and kept a high Vero cell viability (&gt;75%) at concentrations up to 12.5 mg/mL (MTT assay). By M38-A2/M27-A3 (CLSI) against 68 clinical isolates of animals and strains of  Malassezia pachydermatis ,  Sporothrix brasiliensis ,  Microsporum canis, Microsporum gypseum  and  Trichophyton mentagrophytes , all extracts (MIC/MFC ≤3.13–100 mg/mL) were active, except EUG. SCH inhibited and killed  S. brasiliensis  (MIC/MFC 50/90  3.12–12.5 mg/mL) and dermatophytes (MIC/MFC 6.25–25 mg/mL) resistant to ketoconazole and itraconazole. These findings support the promising use of the selected plant extracts as antifungal agents.

natural product research

Chemical, antioxidant and cytotoxic profile of hydroalcoholic extracts of plants from Southern Brazil and their activity against pathogenic fungi isolated from dogs and cats with sensitivity and resistance to conventional antifungals