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Three new xanthones, garcimckeans A-C ( 1-3 ) were isolated from the methanol extract of the stems of  Garcinia mckeaniana  (Clusiaceae). Their structures were established by extensive spectroscopic analysis (HR-ESI-MS and 1 D and 2 D NMR) and by comparison of the spectral data with those reported in the literature. Compounds  1-3  displayed weak cytotoxic activity toward KB, Lu, HepG2, and MCF7 cell lines using the MTT assay with IC 50  values ranging from 71.03 ± 2.93 to 90.40 ± 7.13 µM compared to that of the positive control compound, ellipticine (IC 50 : 1.22 ± 0.10 ∼ 2.44 ± 0.2 µM).

Garcimckeans A-C, three new xanthones from the stems of Garcinia mckeaniana , and their cytotoxic activity