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A new highly oxygenated cycloheptane derivative crustane ( 1 ), along with fourteen known compounds ( 2 – 15 ) were isolated from  Penicillium crustosum  JT-8. The structure of compound  1  was determined by extensive spectroscopic data, DP4+ probability analyses and dimolybdenum CD method. Compound  1  exhibited moderate antibacterial activity against  Staphylococcus aureus  with MIC of 4.0 μg/mL.

A new cycloheptane derivative from the fungus Penicillium crustosum JT-8