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Four new cembrane diterpenes, 1,13-di- epi -13-acetoxy launine P ( 1 ), 13-oxo-thunbergol ( 2 ), isocrassumol B ( 3 ) and 7α, 8α-sarcophine ( 4 ), together with two known launine P ( 5)  and sarcophytonin B ( 6 ), were isolated from the extract of the South China Sea soft coral  Sarcophyton trocheliophorum . The structures were elucidated by spectroscopic analysis, ECD analysis and comparison with literature data. All compounds were tested for their antimicrobial activity and antiviral activity. Compounds  1 ,  2  and  5  were found to exhibit weak antibacterial activity, while  6  showed strong inhibition activity against  Staphylococcus aureus  and  Bacillus subtilis  (MIC0.5 µg/mL). Compounds  2  showed moderate inhibitory effect against influenza A viruses H1N1 with IC 50  of 17.8 μM.

Four new cembranoids from the South China Sea soft coral Sarcophyton trocheliophorum