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A new  α -pyrone, asperpyrone ( 1 ) and two known compounds, stigmasterol ( 2 ) and 7-hydroxy-3-(2,3-dihydroxybutyl)-1(3 H )-Isobenzofuranone ( 3 ) were isolated from the solid rice culture of the endophytic fungus  Aspergillus  sp., an endophytic fungus isolated from the fresh inner tissue of the barks of  Garicinia smeathmannii . Their structures were determined by extensive spectral analysis including 1 D and 2 D NMR, HRESIMS and single-crystal X-ray crystallographic analysis. Asperpyrone ( 1 ) was tested against an axenic culture of  Entamoeba moshkovskii , but did not exhibit any significant amoebicidal activity.

natural product research

Asperpyrone, a rare  α -pyrone metabolite produced by an endophytic fungus  Aspergillus  sp. isolated from  Garicinia smeathmannii  (Planch. &amp; Triana) Oliv.