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A new phenylethanoid, hebitol IV ( 1 ), along with fifteen known glycosides ( 2-16 ), were isolated from water extract of the flower buds of  Buddleja officinalis . Their structures were elucidated on the basis of 1 D-NMR, 2 D-NMR and MS data. Molecular docking showed the potential activities of the natural products against VEGFR-2. Bioassay results revealed that the compounds  10  and  14  exhibited strong inhibitory activity against VEGFR-2 with IC 50  values of 0.51 and 0.32 μM, respectively. Moreover, the potential retinal protective effects of  10  and  14  were then investigated in the mouse model featuring bright light-induced retinal degeneration. The results demonstrated remarkable photoreceptor protective activities of  10  and  14in vivo .

Glycosides from Buddleja officinalis with their protective effects on photoreceptor cells in light-damaged mouse retinas