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Cancer is a hazard life-threatening disease, which affect huge population worldwide. Marine actinomycetes are considered as promising source for potential chemotherapeutic agents. In our study, we carried out metabolic profiling for  Nocardia  sp. UR 86 and  Nocardiopsis  sp. UR 92 that were cultivated from the Red Sea sponge  Amphimedon  sp. to investigate their chemical diversity using different media conditions. The crude culture extracts were subjected to high-resolution mass spectrometry (HRMS) analysis. The chemical profiles of the different extracts of  Nocardia  sp. UR 86 and  Nocardiopsis  sp. UR 92 revealed their richness in diverse metabolites and consequently twenty compounds ( 1–20 ) were annotated. Moreover, the obtained extracts of the differently cultivated  Nocardia  sp. UR 86 and  Nocardiopsis  sp. UR 92 were investigated against three cell lines HepG2, MCF-7 and CACO2 and revealed the targeted cytotoxicity of  Nocardia  sp. and  Nocardiopsis  sp. metabolites against the three cell lines.

Cytotoxic activity of actinomycetes Nocardia sp. and Nocardiopsi s sp. associated with marine sponge Amphimedon sp.