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Two new iridoid glycosides link with phenylpropanoids, rehmanniosides G ( 1 ) and H ( 2 ) along with 11 known compounds, 6-O-( E )-caffeoylajugol ( 3 ), 6- O -( E) -feruloylajugol ( 4 ), verbasoside ( 5 ), jionoside C ( 6 ), acteoside ( 7 ), leucosceptoside A ( 8 ), brachynoside ( 9 ), jionoside B1 ( 10 ), jionoside A1 ( 11 ), isoacteoside ( 12 ) and isomartynoside ( 13 ) were isolated from the roots of  Rehmannia glutinosa  (Gaertn.) DC. Their chemical structures were elucidated on the basis of extensive spectroscopic methods, including 1D, 2D NMR and mass spectra. Compounds  7 − 11  showed significant inhibitory  α -glucosidase with IC 50  values ranging from 261.4 to 408.7 μM (acarbose, IC 50  of 204.2 ± 19.9 μM).

Iridoid glycosides link with phenylpropanoids from Rehmannia glutinosa NATURAL PRODUCT RESEARCH