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Spiranthera odoratissima  A. St.-Hil. (Rutaceae) has been popularly used against abdominal pain and rheumatism. This study aimed at extracting hexane from  S. odoratissima  (HE-SO) leaves to identify and quantify its volatile compounds by GC-MS and GC-FID and to evaluate its antifungal, antileishmanial and antibacterial activities  in vitro . HE-SO exhibited antileishmanial activity against promastigote forms of  Leishmania (Leishmania) amazonensis  (IC 50  = 38.16 µg/mL) and was moderately active against  Xylella fastidiosa  (MIC = 100 µg/mL). HE-SO also showed remarkable antifungal potential against six strains  of Candida  species, i. e.,  C. albicans ,  C. glabrata ,  C. parapsilosis ,  C. krusei ,  C. tropicalis  and  C. orthopsilosis . The lowest MIC values were between 31.25 and 250 µg/mL. Spathulenol (20.2%), τ-cadinol (11.7%), α-cadinol (9.4%), caryophyllene oxide (9.2%) and isoaromadendrene epoxide (8.2%) were the major components identified in HE-SO. Therefore, results showed that HE-SO has promising antileishmanial and antifungal actions.

natural product research

Hexane extract from  Spiranthera odoratissima  A. St.-hil. leaves: chemical composition and its bioactive potential against  Candida  pathogenic species,  Leishmania amazonensis  and  Xylella fastidiosa