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A phytochemical investigation of the liana of  Artabotrys thomsonii  led to the isolation of a new oxoberberine alkaloid, 2,10-dihydroxy-3,9-dimethoxy-8-oxo-protoberberine ( 7 ), along with six known compounds. Their chemical structures were elucidated by 1 D and 2 D NMR spectroscopic methods and HRESI-MS n  data analysis. Compounds  4  and  7  were selected for further  in vitro  investigations. In accordance with expectations from their chemical structures, compounds  7  and  4  showed a clear antioxidant activity in a cell-free assay, with compound  7  being 7-fold more active than  4 . Cytotoxicity, cytostatic and genotoxic effects only occurred at high micromolar concentrations of 50 µM or more. Compound  7  was slightly less effective than compound  4 . A low micromolar concentration of 10 µM did not cause any damaging cellular effects but showed potential for a protection against the micronucleus-inducing effect of reactive oxygen species hydrogen peroxide, although not to a significant extent.

Cytotoxic and genotoxic properties of artathomsonine, a new oxoberberine alkaloid from Artabotrys thomsonii (annonaceae)