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Extracts from  Securidaca longipedunculata  showed antiplasmodial activities against reference clones and clinical isolates using SYBR Green I method. A new benzophenone, 2,3,4,5-tetramethoxybenzophenone ( 1 ) was isolated and characterized along with seven known compounds: 4-hydroxy-2,3-dimethoxybenzophenone ( 2 ); 3-hydroxy-5-methoxybiphenyl ( 3 ), methyl-2-hydroxy-6-methoxybenzoate ( 4 ), benzyl-2-hydroxy-6-methoxybenzoate ( 5 ), 2-hydroxy-6-methoxybenzoic acid ( 6 ), 2,4,5-trimethoxybenzophenone ( 7 ) and 2-methoxy-3,4-methylenedioxybenzophenone ( 8 ). Compounds  1  and  2  showed  ex vivo  antiplasmodial activities (IC 50  28.8 μM and 18.6 μM, respectively); while  5  and  8  showed  in vivo  activities (IC 50  19.7 μM and 14.5 μM, respectively) against D6 strain. In a cytotoxicity assay, all the extracts (with an exception of the MeOH extract of the leaves) and pure compounds were not toxic to the normal LO2 and BEAS cell-lines, while the methanol roots extract (IC 50  66.4 µg/mL against A549, and 77.4 µg/mL against HepG2), compounds  6  (IC 50  22.2 µM against A549) and  7  (IC 50  45.2 µM against HepG2) were weakly active against cancerous cell-lines.

A new benzophenone, and the antiplasmodial activities of the constituents of Securidaca longipedunculata fresen (Polygalaceae)