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Two new tigliane diterpenes, named eupneonoids A ( 1 ) and B ( 2 ), together with four known analogues ( 3–6 ) were isolated from the whole plant of  Euphorbia neorubella  Bruyns. Their structures were deduced based on the detailed spectroscopic analysis. All the isolates displayed cytotoxic effects against A549 human tumor cell lines with IC 50  values ranging from 1.318 to 7.042 μM.

Cytotoxic tigliane diterpenoids from Euphorbia neorubella