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The inhibitory effect of three degraded sesquiterpene lactones,  iso -seco-tanapartholide, arteludooicinolide A and millifolide A isolated from  Achillea millefolium  L., on anti-human lung cancer cells was examined using MTT and reporter gene assays. Millifolide A has significant inhibitory effects on the proliferation of human lung cancer cells probably through inducing cell apoptosis.

Millifolide A, a dimeric ether of degraded sesquiterpene lactones, inhibited the proliferation of human lung cancer cell line A549