English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Ferula assa-foetida , containing organosulfides is widely used in Indian cuisine and traditionally claimed to have several medicinal properties including anticancer properties.  Ferula oil  enriched with organosulfides displayed significant inhibition of the cell growth  in-vitro  against SKOV3 and A549 cancer cells in a dose-dependent manner. This prompted us to investigate and delineate the compounds responsible for the activity. In this endeavor, the employed GC/GC-MS analysis resulted in the indecisive outcome. This led to the development of an expedient isocratic RP-HPLC method for the separation and purification of four major compounds which were further unambiguously characterised as (-)- E -2-butyl propenyl disulfide, (-)- Z -2-butyl propenyl disulfide, (-)-1-(methylthio)propyl( E )-1-propenyl disulfide, and (-)-1-(methylthio)propyl( Z )-1-propenyl disulfide employing  1 H,  13 C, and 2 D NMR. The isolated compounds were further evaluated for their potential against SKOV3 and A549 cell lines where a trisulfide has displayed better activity.

Purification and identification of anticancer organosulfides from Ferula assa-foetida gum: integrative analysis employing GC/GC-MS/RP-HPLC/NMR