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Phytochemical investigation of  Sophora secundiflora  alkaloid fraction led to isolation of one new quinolizidine alkaloid  (1)  13-methoxyanagyrine together with six known ones  (2–7) . The insecticidal activity of 70% methanol extract of leaves of  S. secundiflora ,  S. tomentosa  and the isolated alkaloids were assessed against 3 rd  instar larvae of  Culex pipiens  (Diptera: Culicidae) using different concentrations and mortality rate was recorded.  Sophora tomentosa  extract showed highest mortality rate with median lethal concentration LC 50  3.11 ppm after 24 h and 0.66 ppm after 48 h and anagyrine  (6)  exhibited remarkably insecticidal activity with LC 50  value of 3.42 ppm after 24 h of exposure. Additionally, cytotoxic activity of alkaloid fraction of  S. secundiflora ,  S. tomentosa  and isolated alkaloids was also studied using crystal violet assay against MCF-7 and HEPG-2 cell lines. Anagyrine  (6)  exhibited IC 50  values of 27.3 ± 0.7 and 30.2 ± 0.9 µg/mL against MCF-7 and HEPG-2 cancer cells, respectively.

New quinolizidine alkaloid and insecticidal activity of Sophora secundiflora and Sophora tomentosa against Culex pipiens (Diptera: Culicidae)