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A novel lignan, identified as 4-(3,4-dihydroxyphenyl)-6,7-dimethoxy-3a,4-dihydronaphtho[2,3-c]furan-1(3H)-one, named oleralignan A ( 1 ), together with six known compounds, loliolide ( 2 ), isololiolide ( 3 ), dehydrololiolide ( 4 ), daphnetin ( 5 ), esculetin ( 6 ), and trans-coumaric acid methyl ester ( 7 ) was obtained from  Portulaca oleracea  L., while compounds  3 ,  4 ,  6 , and  7  were isolated from the plant for the first time. Their structures were elucidated using spectroscopic methods, including one- and two-dimensional NMR and high-resolution electrospray ionization time-of-flight mass spectrometry. In addition, the results of activity assay demonstrated that compounds  1 - 7  have anticholinesterase activities.

Seven compounds from Portulaca oleracea L. and their anticholinesterase activities