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Four new aromatic polyketides including two diphenyl ethers (pseudopithoethers A–B,  1 - 2 ), one benzofuranone (pseudopithonone,  3 ) and one xanthone (pseudopithoxanthone,  4 ), along with two known compounds ( 5 - 6 ) and one new naturally occurring hydroquinone (α,2,5-trihydroxyacetophenone,  7 ) were isolated from the marine-derived fungus  Pseudopithomyces maydicus  PSU-AMF350. Their structures were identified by analysis of spectroscopic data. All isolated compounds were tested for antimicrobial activity. Only compound  7  displayed antibacterial activity against methicillin-resistant  Staphylococcus aureus  with the MIC value of 128  µ g/mL and against  S. aureus ,  Acinetobacter baumannii  NPRC005 and  A. baumannii  NPRC007 with the same MIC value of 200  µ g/mL.

New aromatic polyketides from the marine-derived fungus Pseudopithomyces maydicus PSU-AMF350 and their antimicrobial activity