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Staphylococcus aureus  is considered the most common opportunistic pathogen in humans, capable of forming biofilm, increasing the chances of antibiotic resistance and causes several chronic diseases. Biodiversity is a source of inspiration in the search for new agents against these microorganisms. Hitherto, the efficacy of  Hypericum  sp. extracts as an antibacterial agent has already been demonstrated against Gram-positive and Gram-negative bacteria. In this study, we observed that until 4 µg/mL, the  Hypericum brasiliense  extract showed bactericidal activity against a clinical multidrug-resistant  S. aureus  strain (HU25) and also inhibited biofilm formation at 1/2xMIC (confirmed by SEM) and 1/4xMIC. The extract was also proportionally active against 6 h-preformed biofilm to its concentration (1/2xMIC, 1/4xMIC,  p  value ≤ 0.05). These promising results make  Hypericum brasiliense  extract a strong candidate to treat  S. aureus  infections, including anti-biofilm therapy.

‘ Hypericum brasiliense : bactericidal and antibiofilm activity against Staphylococcus aureus in vitro’