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Jasminum  multiflorum  Burm. f. ( J. multiflorum)  is an ornamental plant with traditional medicinal importance. This study aims to evaluate the activity of  J. multiflorum  isolated compounds against hepatocellular carcinoma cells infected with hepatitis C virus (HCV)  in vitro . The  in vitro  anti-viral and anti-oncogenic-related activity were validated by anchorage-independent assay plus transwell migration/invasion and spreading assay. In addition to chromatographic isolation of the active metabolites. The flower extract demonstrated a significant antiviral potential through reducing active viral replication by more than 90%. Study results credit this to specific reduction of viral NS5A and cellular EphA2 protein levels. Molecular docking analysis proved the role of the isolated compounds especially multifloroside, jasfloroside A and jasfloroside B as possible anti HCV molecules.

The role of active metabolites isolated from Jasminum multiflorum flowers against hepatitis C virus infection and related hepatocellular carcinoma