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Chemical investigation of the deep-sea-derived fungus  Aspergillus sydowii  MCCC 3A00324 led to the isolation of one new acremolin type alkaloid (acremolin D,  1 ) and five known alkaloids ( 2‒6 ). The planar structure of  1  was established by the extensive analyses of the NMR and HRESIMS data, while its absolute configuration was assigned by the comparison of the experimental and calculated ECD data. Acremolin D ( 1 ) represented the second analogue of acremolin found in nature. All compounds were evaluated for their cytotoxic activities against six human cancer cell lines (A549, Hela-S3, MCF-7, HepG2, K562, and SF-268). As a result, compounds  1  and  2  exhibited a certain inhibitory effects against the proliferation of the A549, Hela-S3, HepG2, and K562 cell lines at the concentration of 20  µ M.

Acremolin D, a new acremolin alkaloid from the deep-sea sediment derived Aspergillus sydowii fungus