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A new hederagenin-type triterpene saponin; hederagenin 28-O- β -D-galactopyranosyl-(1→6)- β -D-glucopyranosyl ester named sumbulianoside A ( 1 ), together with twelve known saponins were isolated from the  n -butanol extract of  Cephalaria sumbuliana  (Caprifoliaceae) from which, one known saponin, dipsacus saponin A ( 2 ) was isolated, for the first time from  Cephalaria  species. The structures of the isolated compounds were elucidated by 1 D and 2 D NMR and HRESIMS analyses. Cytotoxic activities were investigated on A549, Hela, PANC1, SHSY5Y cells and non-cancerous cell HEK293 by MTT method and immunomodulatory activities were evaluated against activated H3N2 seasonal virus in whole blood by measuring IL-4, IFN- γ , IL-1 β  cytokine level with ELISA. According to the cytotoxicity results, compounds  1  and  2  did not possess significant cytotoxicity, while only compound  2  induced significant IL-4 production (**  p &lt;.001) against H3N2 showing a possible Th2 response and antibody production. All compounds had no effect on cytokine release ( p  &gt; 0.5).

natural product research

A hederagenin-type triterpene saponin, sumbulianoside a from  Cephalaria sumbuliana  and its potent immunomodulatory activity against seasonal flu virus H3N2