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Three new cadinane-type sesquiterpenes, eupatorinones  A-C  ( 1 - 3 ), along with seven known compounds ( 4-10 ), were obtained from the petroleum ether fraction of 95% ethanol extract of  Eupatorium adenophorum  Spreng. The structures of these new compounds were determined by NMR, MS, and ECD spectra analysis. The configuration of compound  3  was established by quantum chemical calculations of NMR chemical shifts and ECD spectra, that matched the experimental data. In addition, compounds  1 ,  3  and  5  increased the glucose uptake in L6 cells by 1.42, 1.21 and 1.60 times, respectively.

Three new cadinane-type sesquiterpenes from Eupatorium adenophorum spreng.