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Two new piericidins A5 ( 1 ) and G1 ( 2 ), a previously synthesized piericidin G2 ( 3 ), and two known piericidins A1 ( 4 ) and A2 ( 5 ) were isolated from the marine-derived  Streptomyces  sp. SCSIO 40063. The structures of  1 - 5  were elucidated by HRESIMS, 1 D, 2 D NMR data analyses and comparisons with the known compounds. Compound  2  showed moderate cytotoxicities against four human tumor cell lines SF-268, MCF-7, HepG2 and A549 with IC 50  values between 10.0 and 12.7 μM.

New piericidin derivatives from the marine-derived streptomyces sp. SCSIO 40063 with cytotoxic activity