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Two previously undescribed triterpenoids ( 1–2 ), along with thirteen known compounds ( 3–15 ) were isolated from a CHCl 3 -soluble extract of the leaves of  Cyclocarya paliurus . Their structures were established on the basis of chemical and spectroscopic approaches. These compounds were assessed for their therapeutic effects on diabetic nephropathy (DN)-evoked fibrosis through High-Glucose and transforming growth factor-β1 (TGF-β1) challenged HK-2 cells. Among them, compounds  3 ,  5  and  8  could remarkedly decrease the level of fibronectin to relieve DN with 27.66 ± 2.77%, 6.09 ± 0.57% and 17.74 ± 5.83% inhibition rate at 10 μM, 10 μM and 1 μM, respectively.

Two new triterpenoids from the leaves of Cyclocarya paliurus (Batalin) Iljinskaja