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Two new lanostane-type triterpenoids, ganoderenicfys A ( 1 ) and B ( 2 ), together with six related known terpenoids ( 3 – 8 ), were isolated and identified from the fruiting body of  Ganoderma applanatum . The structures of these compounds were established on the basis of detailed interpretation of their NMR and HRESIMS data. The absolute configurations of  1  and  2  were determined by quantum chemical electronic circular dichroism (ECD) calculations. All of the isolated compounds were evaluated for their proangiogenic activities in a transgenic fluorescent zebrafish model. Compounds  1 – 6  displayed dose-dependently proangiogenic activity in a PTK787-induced vascular injury zebrafish model, while compounds  1 ,  2  and  4  significantly promoted the angiogenesis. This is the first report for proangiogenic activities of lanostane-type triterpenoids.

New lanostane-type triterpenoids with proangiogenic activity from the fruiting body of Ganoderma applanatum