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Three novel steroidal glycosides ( 1 – 3 ) and a previously described steroidal alkaloid glycoside ( 4 ) have been isolated from the bulbs of  Fritillaria camtschatcensis  (L.) Ker Gawl. (Liliaceae). The structures of novel compounds  1 – 3  were characterized based on NMR spectroscopy and chemical transformations. Compounds  1 – 3  are furospirostanol glycosides bearing a (3 S )-3-hydroxy-3-methylglutaryl moiety at C-26 in the aglycone. Compounds  1 – 4  were evaluated in terms of their cytotoxic activities toward HL-60 human promyelocytic leukemia cells, A549 human lung adenocarcinoma cells, and SBC-3 human lung small cell carcinoma cells. Only  4  showed moderate cytotoxicity against HL-60, A549, and SBC-3 cells with IC 50  values of 22.9, 13.3, and 11.9 µM, respectively. Compound  4  was found to cause necrotic-like cell death in HL-60 cells.

natural product research

Three novel furospirostanol glycosides and a steroidal alkaloid glycoside from the bulbs of  Fritillaria camtschatcensis  (L.) Ker Gawl., and their cytotoxicity