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Two new rocaglamides, 8b- O -5-oxohexylrocaglaol ( 1 ) and elaeagnin ( 2 ), together with twelve known compounds, were isolated from the bark of  Aglaia elaeagnoidea  and the whole tree of  A. odorata . Their structures were determined using spectroscopic methods, mainly 1D and 2D NMR. Cytotoxic activity against HepG2 human liver cancer cells of the isolated compounds was evaluated  in vitro  using the SRB assay. Three rocaglamide derivatives, dehydroaglaiastatin ( 13 ), 8b- O -5-oxohexylrocaglaol ( 1 ) and rocaglaol ( 5 ), exhibited significant effects with IC 50  values of 0.69, 4.77 and 7.37 µM, respectively.

Chemical constituents of Aglaia elaeagnoidea and Aglaia odorata and their cytotoxicity