English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The first synthetic route developed for Podocarflavone A reported from  Podocarpus macrophyllus  and its analogs in 7 steps. Computational analysis for binding with the pantothenate kinase (3AVO) of  Mycobacterium tuberculosis  showed their docking score (ds) in the range of −8.9 to −9.3 Kcal/mol. MD simulations delineated the stability of the protein-ligand complexes in the TIP3P model. MMGBSA and MMPBSA values of  8d  were −42.46 Kcal/mol and −14.58 Kcal/mol, respectively. Further in-vitro antitubercular screening of compounds  8a ,  8d , and  8e  against  M. tuberculosis  H37Ra using XRMA protocol exhibited promising antimycobacterial activity with IC 50  values 21.82   µg/mL, 15.55 µg/mL, and 16.56 µg/mL, respectively. Compounds  8a ,  8d , and  8e  showed antibacterial activity with IC 50  values 41.56 µg/mL, 24.72 µg/mL, and 72.45 µg/mL respectively against the  Staphylococcus aureus .  8a  and  8d  showed inhibition with IC 50  values 39.6 µg/mL and 27.64 µg/mL, respectively, against  Bacillus subtilis . The present study could help in the further development of lead molecules against tuberculosis.

natural product research

The first synthesis of podocarflavone A and its analogs and evaluation of their antimycobacterial potential against  Mycobacterium tuberculosis  with the support of virtual screening